Defending European champions Manchester United drew Portuguese title holders FC Porto during Friday's Champions League quarter-final draw at UEFA headquarters in Nyon, Switzerland.
The match brings back memories of 2004, when then Porto boss Jose Mourinho charged up the Old Trafford touchline in delight after a 90th-minute Costinha goal took the Portuguese side through at the expense of the English team.
Liverpool drew Chelsea yet again and means Rafa Benitez's 2005 champions will face last season's beaten finalists for the fourth time in the knock-out stages in five seasons. The duo have also previously met in the group stages of the competition.
Arsenal will play their first leg away to Villarreal in a repeat of the semi-final of 2006, although the Gunners played the first match at home on that occasion and went through 1-0 on aggregate after success at Highbury.
Barcelona drew Bayern Munich.
The quarter-finals will take place on April 7-8, with the return legs the following week. The draw for the semi-finals was also made in Switzerland.
The winners of Liverpool's match against Chelsea will face the winners of Barcelona's match against Bayern for a place in the final.
United will take on Arsenal for a place in the Rome showdown - assuming both Premier League teams win their quarter-final ties.
The first leg of the semis is due to take place on April 28-29, with the return matches going ahead the following week.