The findings from the current study demonstrate that three doses of the COVID-19 NVX-CoV2373 vaccine significantly improved neutralization of the SARS-CoV-2 Omicron BA.4/BA.5 and BA.1 subvariants with responses that were comparable to those achieved with three mRNA vaccine doses.
Notably, enhanced binding antibody levels were detected six months after two NVX-CoV2373 doses. Thus, future studies should evaluate NVXCoV2373 neutralization at later time points, as the longevity of different vaccine platforms can vary.
Since the SARS-CoV-2 Omicron BA.4 variant has become the dominant circulating strain in multiple regions, the study findings emphasize the potential use of NVX-CoV2373 vaccination as a booster dose, particularly in regions with limited resources.