奥兹海默研究协会国际大会上的一些有意思的/有些奇葩的研究报告 dudaan2022-08-08 13:34:18

出处：https://aaic.alz.org/releases_2022/overview.asp

1）遭受种族歧视会增加认知能力下降的风险

2）孕期高血压会增加失智症的风险

3）因新冠引起的嗅觉长期丧失会使奥兹海默症的风险加倍

4）超级精加工食品（苏打、早餐麦片、薯片、冷冻垃圾食品等）会加速失智

5）社会地位低和长期低工资会增加记忆力下降的速度和失智症的风险

Experiences of Racism Associated with Poor Memory, Increased Cognitive Decline
Experiences of structural, interpersonal and institutional racism are associated with lower memory scores and worse cognition in midlife and old age, especially among Black individuals.

• In a study of nearly 1,000 middle-aged community-dwelling adults (55% Latinx; 23% Black; 19% White), exposure to interpersonal and institutional racism was associated with lower memory scores; the associations were strongest in Black individuals. Experiences of structural racism were associated with lower episodic memory among all racial and ethnic groups included in the study.
• In a study of 445 Asian, Black, Latino, White and multiracial people age 90 and above, individuals who experienced wide-ranging discrimination throughout life had poorer long-term memory in late life compared to those who experienced little to no discrimination.

 

History of Hypertensive Disorders During Pregnancy Linked to Increased Risk of Dementia
Hypertensive disorders of pregnancy (HDP) — conditions of high blood pressure including chronic/gestational hypertension and preeclampsia — have been strongly linked to heart disease in later life, but before today, little research has connected these disorders with cognition. Experiences of high blood pressure disorders during pregnancy are associated with an increased risk of vascular dementia and accelerated brain aging, according to several studies at AAIC 2022:

• Women with a history of HDP were more likely to develop vascular dementia — a decline in thinking skills caused by conditions that block or reduce blood flow to the brain — later in life, compared to women with non-hypertensive pregnancies.
• Experience of HDP, specifically high blood pressure during pregnancy, was associated with white matter pathology, a predictor of accelerated cognitive decline, 15 years after pregnancy.
• Women with severe preeclampsia had significantly higher levels of beta amyloid, an Alzheimer’s-related brain change, as measured in blood compared to those with non-hypertensive pregnancies.

 

Persistent Loss of Smell Due to COVID-19 Closely Connected to Long-Lasting Cognitive Problems, and ICU Stays May Double Risk of Dementia in Older Adults
New insights into factors that may predict, increase or protect against the impact of COVID-19 and the pandemic on memory and thinking skills were revealed by multiple studies at AAIC 2022. A research group from Argentina found that persistent loss of the sense of smell may be a better predictor of long-term cognitive and functional impairment than severity of the initial COVID-19 disease. In a large study population from nine Latin American countries, experiencing a positive life change during the pandemic, such as more quality time with friends and family, reduced the negative impact of the pandemic on memory and thinking skills. Finally, hospitalization in the intensive care unit (ICU) was associated with double the risk of dementia in older adults, according to Rush Alzheimer’s Disease Center in Chicago. These findings could be significant given the tremendous upsurge in ICU hospitalizations during the COVID-19 pandemic.

Ultra-Processed Foods May Speed Cognitive Decline
A study presented at AAIC 2022 finds that people who eat large amounts of ultra-processed foods have a faster decline in cognition. Researchers studied 10,775 people over eight years and found that high consumption (more than 20% of daily intake) of ultra-processed foods led to a 28% faster decline in global cognitive scores, including memory, verbal fluency and executive function. Ultra-processed foods go through significant industrial processes and contain large quantities of fats, sugar, salt, artificial flavors/colors, stabilizers and/or preservatives. Examples include sodas, breakfast cereals, white bread, potato chips and frozen “junk” foods.

Lower Socioeconomic Status, Persistent Low Wages Linked to Dementia Risk and Faster Memory Decline
Socioeconomic status (SES) — reflecting both social and economic measures of a person’s work experience, and of an individual’s or family’s economic access to resources and social position — has been linked to both physical and psychological health and well-being. Socioeconomic deprivation, including neighborhood disadvantages and persistent low wages, are associated with higher dementia risk, lower cognitive performance and faster memory decline, according to several studies:

• Individuals who experience high socioeconomic deprivation — measured using income/wealth, unemployment rates, car/home ownership and household overcrowding — are significantly more likely to develop dementia compared to individuals of better socioeconomic status, even at high genetic risk.
• Lower-quality neighborhood resources and difficulty paying for basic needs were associated with lower scores on cognitive tests among Black and Latino individuals.
• Compared with workers earning higher wages, sustained low-wage earners experienced significantly faster memory decline in older age.
• Higher parental SES was associated with increased resilience to the negative effects of Alzheimer’s marker ptau-181, better baseline executive function and slower cognitive decline in older age.

这个结论略仓促：“因新冠引起的嗅觉长期丧失会使奥兹海默症的风险加倍”。　

现代科学研究能出真成果的毕竟是少数。

另外，感觉是美国/西方的科学研究也要讲“政治”

是，所谓”科学和司法独立“那只是理想，而现实中近乎不可能。

这病相关研究里，最脏的是那些药物研发相关的。几乎全是假药。

只有牲口药是真的，就是你吃的那种

最近看到两个有明显缺陷的baby, 一个是弱视，一个是头上有特红的不能愈合的伤口。父母都很年轻