[NIH] 看文章，探结论，论事不论人，没有权威只有数据。上帝已死，很适合现在的医疗圈。权威已死，科普必须谦虚。 枫林晓2022-08-29 18:17:25

The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.

16. Conclusions

There has been an unwavering message about the safety and efficacy of mRNA vaccinations against SARS-CoV-2 from the public health apparatus in the US and around the globe. The efficacy is increasingly in doubt, as shown in a recent letter to the Lancet Regional Health by Günter Kampf (2021b). Kampf provided data showing that the vaccinated are now as likely as the unvaccinated to spread disease. He concluded: “It appears to be grossly negligent to ignore the vaccinated population as a possible and relevant source of transmission when deciding about public health control measures.” Moreover, the inadequacy of phase I, II, and III trials to evaluate mid-term and long-term side effects from mRNA genetic vaccines may have been misleading on their suppressive impact on the innate immunity of the vaccinees.

In this paper, we call attention to three very important aspects of the safety profile of these vaccinations. First is the extensively documented subversion of innate immunity, primarily via suppression of IFN-α and its associated signaling cascade. This suppression will have a wide range of consequences, not the least of which include the reactivation of latent viral infections and the reduced ability to effectively combat future infections. Second is the dysregulation of the system for both preventing and detecting genetically driven malignant transformation within cells and the consequent potential for vaccination to promote those transformations. Third, mRNA vaccination potentially disrupts intracellular communication carried out by exosomes, and induces cells taking up spike glycoprotein mRNA to produce high levels of spike-glycoprotein-carrying exosomes, with potentially serious inflammatory consequences. Should any of these potentials be fully realized, the impact on billions of people around the world could be enormous and could contribute to both the short-term and long-term disease burden our health care system faces.

Given the current rapidly expanding awareness of the multiple roles of G4s in regulation of mRNA translation and clearance through stress granules, the increase in pG4s due to enrichment of GC content as a consequence of codon optimization has unknown but likely far-reaching consequences. Specific analytical evaluation of the safety of these constructs in vaccines is urgently needed, including mass spectrometry for identification of cryptic expression and immunoprecipitation studies to evaluate the potential for disturbance of or interference with the essential activities of RNA and DNA binding proteins.

It is essential that further studies be conducted to determine the extent of the potential pathological consequences outlined in this paper. It is not practical for these vaccinations to be considered part of a public health campaign without a detailed analysis of the human impact of the potential collateral damage. VAERS and other monitoring systems should be optimized to detect signals related to the health consequences of mRNA vaccination we have outlined. We believe the upgraded VAERS monitoring system described in the Harvard Pilgrim Health Care, Inc. study, but unfortunately not supported by the CDC, would be a valuable start in this regard (Lazarus et al., 2010).

In the end, billions of lives are potentially at risk, given the large number of individuals injected with the SARS-CoV-2 mRNA vaccines and the broad range of adverse outcomes we have described. We call on the public health institutions to demonstrate, with evidence, why the issues discussed in this paper are not relevant to public health, or to acknowledge that they are and to act accordingly. Furthermore, we encourage all individuals to make their own health care decisions with this information as a contributing factor in those decisions.

谷歌翻译

抽象的
为了应对 Covid-19 的公共卫生危机，mRNA SARS-CoV-2 疫苗上市。在传染病的背景下使用 mRNA 疫苗没有先例。疫苗 mRNA 的许多改变隐藏了 mRNA 免受细胞防御的影响，并促进了更长的生物半衰期和刺突蛋白的高产量。然而，对疫苗的免疫反应与对 SARS-CoV-2 感染的免疫反应非常不同。在本文中，我们提供的证据表明，疫苗接种会严重损害 I 型干扰素信号，从而对人类健康产生多种不利影响。吸收了疫苗纳米颗粒的免疫细胞将大量含有刺突蛋白的外泌体以及关键的 microRNA 释放到循环中，这些 microRNA 在远处的受体细胞中诱导信号传导反应。我们还确定了蛋白质合成和癌症监测的监管控制中潜在的严重干扰。这些干扰可能与神经退行性疾病、心肌炎、免疫性血小板减少症、贝尔氏麻痹、肝病、适应性免疫受损、DNA损伤反应受损和肿瘤发生有因果关系。我们展示了来自 VAERS 数据库的证据来支持我们的假设。我们相信，对 mRNA 疫苗的全面风险/收益评估会质疑它们对公共卫生的积极贡献。

图 1

16. 结论
美国和全球的公共卫生机构一直在坚定不移地发出关于 SARS-CoV-2 mRNA 疫苗的安全性和有效性的信息。正如 Günter Kampf (2021b) 最近给《柳叶刀地区健康》的一封信中所显示的那样，疗效越来越受到质疑。 Kampf 提供的数据显示，接种疫苗的人现在与未接种疫苗的人一样可能传播疾病。他总结道：“在决定公共卫生控制措施时，忽视接种疫苗的人群可能是相关的传播源，这似乎是严重疏忽。”此外，I、II 和 III 期试验不足以评估 mRNA 基因疫苗的中期和长期副作用，这可能会误导它们对疫苗接种者先天免疫的抑制作用。

在本文中，我们提请注意这些疫苗接种安全性的三个非常重要的方面。首先是广泛记录的先天免疫颠覆，主要是通过抑制 IFN-α 及其相关的信号级联。这种抑制将产生广泛的后果，其中最重要的是包括潜伏病毒感染的重新激活和有效对抗未来感染的能力降低。其次是用于预防和检测细胞内基因驱动的恶性转化的系统失调，以及由此产生的疫苗接种促进这些转化的潜力。第三，mRNA 疫苗接种可能会破坏外泌体进行的细胞内通讯，并诱导细胞摄取刺突糖蛋白 mRNA 以产生高水平的携带刺突糖蛋白的外泌体，从而可能产生严重的炎症后果。如果充分发挥这些潜力中的任何一个，对全球数十亿人的影响可能是巨大的，并可能加剧我们的医疗保健系统面临的短期和长期疾病负担。

鉴于目前对 G4s 在通过应激颗粒调节 mRNA 翻译和清除中的多种作用的认识迅速扩大，由于密码子优化导致 GC 含量富集导致 pG4s 的增加具有未知但可能影响深远的后果。迫切需要对疫苗中这些构建体的安全性进行具体的分析评估，包括用于鉴定隐蔽表达的质谱和免疫沉淀研究，以评估干扰或干扰 RNA 和 DNA 结合蛋白的基本活性的可能性。

必须进行进一步的研究以确定本文概述的潜在病理后果的程度。如果不详细分析潜在附带损害对人类的影响，将这些疫苗接种视为公共卫生运动的一部分是不切实际的。应优化 VAERS 和其他监测系统，以检测与我们概述的 mRNA 疫苗接种的健康后果相关的信号。我们相信，哈佛 Pilgrim Health Care, Inc. 研究中描述的升级后的 VAERS 监测系统，但不幸的是没有得到 CDC 的支持，将是这方面的一个有价值的开端（Lazarus 等，2010）。

最终，鉴于大量个体注射了 SARS-CoV-2 mRNA 疫苗以及我们描述的广泛的不良后果，数十亿人的生命可能处于危险之中。我们呼吁公共卫生机构用证据证明为什么本文讨论的问题不相关