https://neurosciencenews.com/conolidine-natural-pain-killer-18555/amp/
Summary: Conolidine, a natural painkiller derived from the pinwheel flower and frequently used in Chinese medicine, interacts with a newly identified opioid receptor that regulates natural opioid peptides produced in the brain.
PS
The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7
https://www.nature.com/articles/s41392-021-00548-w