"¡Happy Birthday Guadalupe!" is a Christmas song by Las Vegas rock band The Killers featuring Wild Light and Mariachi El Bronx released as a Digital Download on World Aids Day, December 1, 2009.
The song continues on with The Killers' tradition of releasing a Christmas song every year, and will be the fourth consecutive annual Christmas song since 2006, the others being "A Great Big Sled", "Don't Shoot Me Santa" and "Joseph, Better You Than Me". All proceeds from the Christmas singles benefit the Product Red campaign.