Antibodies that can neutralise SARS-CoV-2 Omicron variant identified

A study has revealed four classes of antibodies that can neutralise Omicron by targeting one of four areas of the spike protein present in SARS-CoV-2 variants.
https://www.drugtargetreview.com/news/100547/antibodies-that-can-neutralise-sars-cov-2-omicron-variant-identified/

A team of scientists from the University of Washington School of Medicine in Seattle, US, have identified antibodies that neutralise Omicron and other SARS-CoV-2 variants. According to the team, these antibodies target areas of the virus spike (S) protein that remain essentially unchanged as the viruses mutate.

 

By identifying the targets of these broadly neutralising antibodies on the S protein, it might be possible to design vaccines and antibody treatments that will be effective against not only the Omicron variant but other variants that may emerge in the future. 

“This finding tells us that by focusing on antibodies that target these highly conserved sites on the S protein, there is a way to overcome the virus’ continual evolution,” said Associate Professor David Veesler, co-lead researcher of the study

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Antibodies from people who had previously been infected and those who had received the Sputnik V or Sinopharm vaccines as well as a single dose of Johnson & Johnson had little or no ability to neutralise the Omicron variant’s entry into cells. Antibodies from people who had received two doses of the Moderna, Pfizer/BioNTech and AstraZeneca vaccines retained some neutralising activity, albeit reduced by 20- to 40-fold, much more than any other variants.

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PS

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

https://www.nature.com/articles/s41586-021-04386-2

 

Excellent.

意义有限。打了疫苗这么长时间了，到如今尚无明确一个对应于抗感染或是防重症的中和抗体确定值

这些研究都是 测抗体浓度。 那如果抗体识别病毒的能力已经降低了， 再高的浓度又有什么用呢？

找到抗感染或是防重症的中和抗体确定值，是不可能的任务。