nature: Cross-reactive serum and memory B-cell responses to spik fuz2021-05-30 12:45:24

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

https://www.nature.com/articles/s41467-021-23074-3

Abstract

Pre-existing immunity to seasonal endemic coronaviruses could have profound consequences for antibody responses to SARS-CoV-2, induced from natural infection or vaccination. A first step to establish whether pre-existing responses can impact SARS-CoV-2 infection is to understand the nature and extent of cross-reactivity in humans to coronaviruses. Here we compare serum antibody and memory B cell responses to coronavirus spike proteins from pre-pandemic and SARS-CoV-2 convalescent donors using binding and functional assays. We show weak evidence of pre-existing SARS-CoV-2 cross-reactive serum antibodies in pre-pandemic donors. However, we find evidence of pre-existing cross-reactive memory B cells that are activated during SARS-CoV-2 infection. Monoclonal antibodies show varying degrees of cross-reactivity with betacoronaviruses, including SARS-CoV-1 and endemic coronaviruses. We identify one cross-reactive neutralizing antibody specific to the S2 subunit of the S protein. Our results suggest that pre-existing immunity to endemic coronaviruses should be considered in evaluating antibody responses to SARS-CoV-2.

 

这是自然然杂志的原文。其真正临床意义，解释了在新冠快速检测中的出现的假阳性。

单从摘要上看，此论文所研究的似乎是新冠抗体，新冠的快速检验查的是抗体还是病毒本身的基因序列？

快速检测都是测抗原抗体的，核酸测序目前的技术还是需要相对较长的时间

同一类病毒，享有类似生物结构和遗传物质。冠状病毒的冠，是该类病毒的基本特征。但每种病毒的冠是不一样的，如国王的冠，一看就知道

多谢多谢。解释得真清楚。

原来如此。快速检测和核酸PCR检测的原理都不一样。