https://www.nature.com/articles/d41586-021-02096-3
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The analysis adds to a growing body of evidence that a person’s levels of ‘neutralizing’ antibodies, which block SARS-CoV-2 from infecting cells, predict whether that person will become infected.
A robust predictive marker, known as a correlate of protection, could help regulators to approve new vaccines without requiring large clinical trials. It could also help them to assess the need for booster shots to guard against emerging viral variants. The study “is an important step in further validating the use of neutralization titre as a correlate of protection”, says Miles Davenport, an immunologist at the University of New South Wales in Sydney, Australia.
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PS
https://www.nejm.org/doi/10.1056/NEJMoa2109072